Table 2.
Human dendritic cells in the skin of normal individuals and in psoriatic skin.
| Location | Human DC in the skin | Steady state | Cell surface markers in steady state* | Psoriatic skin | Cell surface markers in lesional skin** | Function in psoriasis | Equivalent cells in mice |
|---|---|---|---|---|---|---|---|
| Epidermis | LC | Present | CD11c + CD1a + CD1c(BDCA-1) + CD207(Langerin) + | Present | CD1a + CD1c(BDCA-1) + CD11c + Langerin (CD207) + | Controversial | Mouse LC |
| Dermis | CD1c + DC(cDC1) | Present | CD11c+CD1a+CD1c(BDCA-1)+ | Decreased | CD1a+CD1c(BDCA-1)+CD11c+ | Induction and proliferation of Th1/17 cells and cytokine production | Mouse CD11b+DC |
| CD141 + DC(cCD2) | Present | CD11low
CD1a + CD1c(BDCA-1)low/int CD141(BDCA-3)+ |
Increased | CD11c + CD141(BDCA-3)+ | Induction and proliferation of Th1/17 cells and cytokine production | Mouse CD103+DC | |
| pDC | Absent | Present | CD11c-CD123 + CD303(BDCA-2) + | Production of IFN-α and activation and maturation of dermal DC | Mouse pDC | ||
| iDC-Tip-DC- slan DC | Absent | Present | CD11c + CD206 + | Production of TNF-α, iNOS, IL-23 | Mouse iDC |
DC, dendritic cells; LC, Langerhans cell; pDC, plasmacytoid cell; iDC, inflammatory cell.
*Cell surface markers on the indicated DC in the steady state.
**Cell surface markers on the indicated DC in lesional skin.