FIGURE 1.

Localization of multiple types of immune cells in the liver lobule. The liver comprises hexagonal units called lobules. Blood from the portal vein and hepatic artery flows through liver sinusoids to the central vein. Hepatocytes are arranged around the sinusoid and form the space of Dissé. KCs are located in the space of Dissé and in close contact with HSCs, hepatocytes, and LSECs, allowing them to filter bacteria passing through the sinusoid. Immune cells such as neutrophils, T cells, iNKT cells, and conventional NK cells (cNK) are enriched in the hepatic sinusoids, patrolling the whole liver, whereas liver resident NK cells (LrNK) are located in the space of Dissé.