Table 3.
Pharmacokinetic Parameters of PTX in Mice After Intravenous Administration at a Dose of 18.0 mg/kg
| Parameter | Unit | PTX/CBP | Lip-PTX/CBP | ES-PEG-Lip-PTX/CBP |
|---|---|---|---|---|
| t1/2α | h | 0.038 ± 0.046 | 0.556 ± 0.298 | 0.649 ± 0.105 |
| t1/2β | h | 0.841 ± 0.164 | 3.221 ± 1.243 | 8.698 ± 3.384**# |
| AUC(0–t) | mg/L × h | 56.0 ± 26.9 | 110.1 ± 9.8 | 424.9 ± 91.0***## |
| AUC(0-∞) | mg/L × h | 56.0 ± 26.9 | 112.1 ± 10.5 | 437.0 ± 104.2***## |
| MRT | h | 0.894 ± 0.409 | 2.952 ± 0.916 | 9.304 ± 3.029**# |
| CL | L/h/kg | 0.374 ± 0.168 | 0.162 ± 0.016 | 0.043 ± 0.009* |
Note: The values were presented as the mean ± SD (n = 3). * p < 0.05, ** p < 0.01 and *** p < 0.001 compared with PTX/CBP; # p < 0.05 and ## p < 0.01 compared with Lip-PTX/CBP.
Abbreviations: t1/2α, distribution half-life; t1/2β, elimination half-life; AUC, area under the curve; MRT, mean retention time; CL, rate of clearance.