Table 2.

Bivariable and multivariable survival analysis for patients with pT4b locally advanced gastric cancer

	Bivariable HR (95% CI)*	Multivariable HR (95% CI)*
Age (years)
18–49	Reference	Reference
50–64	0.84 (0.63–1.13)	0.87 (0.65–1.17)
65–74	0.97 (0.72–1.31)	1.02 (0.75–1.38)
≥ 75	1.42 (1.07–1.90)	1.20 (0.88–1.65)
Female sex	1.21 (1.02–1.43)	1.11 (0.93–1.33)
Race
White	Reference
African-American	0.84 (0.68–1.04)
Asian-American	0.77 (0.56–1.07)
Hispanic Ethnicity
No	Reference
Yes	0.82 (0.62–1.08)
Charlson-Deyo score
0	Reference	Reference
1	1.03 (0.84–1.26)	0.87 (0.71–1.08)
≥ 2	0.97 (0.71–1.33)	0.85 (0.61–1.19)
MVR
Yes	1.04 (0.88–1.24)
Gastrectomy type
Subtotal	Reference
Total	1.14 (0.95–1.36)
Gastrectomy unspecified	1.36 (0.96–1.94)
Pathologic nodal stage
0	Reference	Reference
1	1.54 (1.16–2.05)	1.50 (1.12–2.00)
2	1.30 (0.98–1.72)	1.31 (0.98–1.75)
3	1.68 (1.31–2.14)	1.46 (1.13–1.88)
Resection margin status
Positive	1.76 (1.48–2.10)	1.63 (1.35–1.97)
Neoadjuvant chemotherapy
Yes	0.79 (0.64–0.98)	0.81 (0.64–1.03)
Neoadjuvant radiation
Yes	0.79 (0.42–1.48)
Adjuvant chemotherapy
Yes	0.60 (0.51–0.72)	0.64 (0.51–0.80)
Adjuvant radiation therapy
Yes	0.63 (0.52–0.77)	0.77 (0.61–0.98)
Treatment at a high-volume center
Yes	0.73 (0.60–0.89)	0.76 (0.68–0.85)
Treatment at a high-completion center
Yes

^*Hazard ratios and 95% confidence intervals