Table 3.

Bivariable and multivariable survival analysis for patients with pT4a and pT4 locally advanced gastric cancer who underwent margin-negative gastrectomy with multivisceral resection

	Bivariable HR (95% CI)*	Multivariable HR (95% CI)*
Age (years)
18–49	Reference	Reference
50–64	0.98 (0.67–1.45)	0.93 (0.62–1.40)
65–74	0.78 (0.51–1.18)	0.84 (0.54–1.30)
≥ 75	1.54 (1.03–2.30)	1.36 (0.89–2.07)
Female sex	0.99 (0.62–1.59)	1.32 (1.02–1.71)
Race
White	Reference
African-American	1.11 (0.82–1.50)
Asian-American	0.89 (0.55–1.42)
Hispanic ethnicity
Yes	1.07 (0.75–1.53)
Charlson-Deyo score
0	Reference	Reference
1	1.57 (1.17–2.09)	1.41 (1.05–1.90)
≥ 2	1.13 (0.72–1.75)	1.29 (0.74–1.92)
Gastrectomy type
Subtotal	Reference
Total	1.12 (0.86–1.45)
Gastrectomy unspecified	1.05 (0.72–1.55)
MVR
Yes	0.75 (0.47–1.20)
Primary tumor stage
T4b	1.17 (0.92–1.49)
Pathologic nodal stage
0	Reference	Reference
1	1.36 (0.90–2.06)	1.61 (1.06–2.47)
2	1.18 (0.79–1.76)	1.45 (0.96–2.19)
3	2.35 (1.69–3.27)	2.69 (1.91–3.78)
Neoadjuvant chemotherapy
Yes	0.88 (0.66–1.16)
Neoadjuvant radiation
Yes	0.72 (0.27–1.94)
Adjuvant chemotherapy
Yes	0.59 (0.46–0.75)	0.75 (0.55–1.03)
Adjuvant radiation
Yes	0.64 (0.49–0.84)	0.77 (0.55–1.08)

^*Hazard ratios and 95% confidence intervals