Table 4.
Bristol Stool Form Scale Score, Patient Satisfaction, and Time to Bowel Movement After Treatment With Elobixibat Before Breakfast, Lunch, or Dinner
| Item | Before breakfast (n = 643) | Before lunch (n = 26) | Before dinner (n = 162) | |||||
|---|---|---|---|---|---|---|---|---|
| Baseline | Week 4 | Baseline | Week 4 | Baseline | Week 4 | |||
| Bristol Stool Form Scale score | 2.3 ± 1.5 (582) | 3.9 ± 1.1a (624) | 2.6 ± 1.1 (26) | 4.0 ± 0.9a (26) | 2.3 ± 1.3 (143) | 3.9 ± 1.0a (158) | ||
| Patient satisfaction | ||||||||
| Satisfaction | 3 (0.5) | 256 (40.2) | 0 | 8 (30.8) | 0 | 58 (36.5) | ||
| Slight satisfaction | 26 (4.4) | 233 (36.6) | 4 (16.0) | 13 (50.0) | 12 (8.3) | 68 (42.8) | ||
| Slight dissatisfaction | 183 (30.8) | 86 (13.5) | 10 (40.0) | 4 (15.4) | 55 (38.2) | 24 (15.1) | ||
| Dissatisfaction | 383 (64.4) | 62 (9.7) | 11 (44.0) | 1 (3.8) | 77 (53.5) | 9 (5.7) | ||
| No evaluation | 48 (−) | 6 (−) | 1 (−) | 0 | 18 (−) | 3 (−) | ||
| Time to bowel movement (hr) | ||||||||
| Mean ± SD (n) | ND | 5.6 ± 5.7 (327) | ND | 9.9 ± 6.1 (14) | ND | 8.5 ± 6.0 (96) | ||
| Median | 5.0 | 8.0 | 8.0 | |||||
aP < 0.001 vs baseline, Wilcoxon signed-rank test for Bristol Stool Form Scale score.
ND, not determined; n, number of patients with each item at each visit.
Data are presented as mean ± SD (n) or n (%).