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. 2022 Jun 13;18(10):3944–3960. doi: 10.7150/ijbs.70889

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CircFAT1 promotes A549 LUAD cell tumorigenesis in vivo. (A and B) Xenograft assay showing A549 cells with circFAT1 knockdown (A) or overexpression (B) by lentiviruses inhibited or promoted tumor formation, respectively (n=5). (C and D) Volume of the xenograft tumors under circFAT1 knockdown (C) and overexpression (D) conditions. The volumes of tumors were estimated by measuring sizes every other day. (E) Weight of harvested xenograft tumors derived from A549 cells with circFAT1-knockdown (Upper) or overexpression (Lower). (F) Immunofluorescent staining of xenograft tumors showing that the protein levels of IRS2, CCND1 and Ki67 were decreased in circFAT1-knocked-down tumor tissues and increased in circFAT1-overexpressed tissue. Scale bar, 100 µm. Data are presented as mean ± SD; *P < 0.05, **P < 0.01, ***P < 0.001.