Skip to main content
. 2022 Jun 13;18(10):3944–3960. doi: 10.7150/ijbs.70889

Figure 6.

Figure 6

Knockdown of circFAT1 further reduces the tumor size of DDP-treated mice. (A and B) Growth curves of A549 (A) and PC9 (B) cells with circFAT1 knockdown and/or DDP treatment as evaluated by CCK8 assay. (C) Growth curves of xenograft tumors estimated by measuring the sizes every three days during 33 days of experimental period. (D) Xenograft tumors derived from A549 cells treated with shcircFAT1 or shNC and different dosages of DDP (n=5). (E) The weight of dissected xenograft tumors shown in (D) to demonstrate that knockdown of circFAT1 enhanced the effectiveness of DDP, and that 9 mg/kg/week of DDP with circFAT1 knockdown reduced tumor mass more than that of higher dosage of DDP treatment (14 mg/kg/week) without circFAT1 knockdown (shNC). Data in (A, B and E) are presented as mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001.