Table 1.

Gut microbiota involved in therapeutic responses and side-effects of GI cancer

Treatment	Gut Microbiota	Cancer type	Drug	Response/effect	Ref.
Response effect in chemotherapy	F. nucleatum	CRC	5-Fu Oxaliplatin	poor	109,110,111
		ESCC	CDDP Docetaxel
	Gammaprotect-obacteria	CRC	Gemcitabine	poor	112
	Clostridium	LARC		poor	119
	Enterococcus hirae	CRC	CTX	favorable	115
	Barnesiella intestinihominis	CRC	CTX	favorable	115
Response effect In ICIs	Prevotella	CRC	anti-PD-1/PD-L1	favorable	143
	Ruminococcaceae	CRC	anti-PD-1/PD-L1	favorable	143
	Lachnospiraceae	CRC	anti-PD-1/PD-L1	favorable	143
	Eubacterium	CRC	anti-PD-1/PD-L1	favorable	143
	Lactobacillus	CRC	anti-PD-1/PD-L1	favorable	143
	Streptococcus	CRC	anti-PD-1/PD-L1	favorable	143
	Bifidobacterium pseudolongum	CRC	anti-CTLA-4/anti-PD-L1	favorable	149
Therapeutic side-effect	Lactobacillus		oxaliplatin	favorable	113
	Roseburia		radiotherapy	poor	123
	Clostridium IV		radiotherapy	poor	123
	Faecalibacterium		radiotherapy	poor	123
	Lactobacillus rhamnosus		radiotherapy	favorable	125
	Lachnospiraceae		radiotherapy	favorable	126
	Enterococcaceae		radiotherapy	favorable	126