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Enrichment of dietary fiber derived-SCFA attenuates NLRP3 activation through GPR43 signaling. Representative western blot of GPR43, NLRP3, pro-caspase-1, cleaved-caspase-1 and IL-1β (A), as well as K48- and K63-linked ubiquitylation (B) in atrial tissue of mice fed with normal, low-fiber, high-fiber and low fiber+SCFA, with GAPDH as an endogenous control. A.U., arbitrary units. *, P<0.05; **, P<0.01; ***, P<0.001; n=3-6; data are mean±SEM; student's t-test.
