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Brief description of mesenchymal stem cell-osteoblast (MSC-OB) lineage and monocyte-macrophage (MC-Mφ) lineage in bone tissues and their different modes of communication. (a) Conventional secretory pathways (including direct cell-cell contact and chemical receptor-mediated events) and (b) extracellular vesicles (EVs). Schematic picture was created with BioRender.
