Figure 5.

Validation and evaluation prognostic miRNA-related signature for hepatocellular carcinoma (HCC) in testing cohort. A. Kaplan-Meier survival curves for the high- and low-risk subgroups. B. Time dependent receiver operating characteristic (ROC) curves of prognostic signature predicting the overall survival (OS) at 1-, 2-, and 3-years. C. ROC curves for prognostic signature and other clinicalpathological characteristics in predicting the OS of HCC patients. D. Distribution of miRNA-related risk score between the high- and low-risk subgroups. E. Distribution of survival status of HCC patients in high- and low-risk subgroups. F. Heatmap showed the relationship between the expression levels of six miRNAs and other clinicopathological factors. G, H. Principal component analysis (PCA) and t-distributed stochastic neighbor embedding (t-SNE) of prognostic signature between the high-risk and low-risk subgroups. I. Univariate Cox regression analyses of prognostic signature and other clinicopathological characteristics. J. Multivariate Cox regression analyses prognostic signature and other clinicopathological characteristics.