Figure 2.

Eplerenone improves the long-term spatial learning and memory ability of SHRs in Morris water maze (MWM) test. A. Bar graph showing the average escape latencies of rats when searching for the hidden platform in 5 consecutive training days. B. Representative swimming traces of rats on the fifth day of spatial navigation training. The large circle presents the water maze pool, and the small circle represents the hidden platform. The green dot represents the start position and the red dot represents the end position of rats. C. In probe test, bar graph showing the percentage of swimming time of rats spent in the target quardant. D. In probe test, bar graph showing the numbers of crossing the platform. E. Representative swimming traces of rats in the probe test. F. Bar graph showing the average swimming time of arrival at the visible platform. G. Line graph showing no significant difference in the average swimming speeds among four groups. Data are expressed as mean ± SD, N = 12. *P < 0.05, **P < 0.01, ***P < 0.001 vs. SHR-Veh.