Table 1.
Effects of eplerenone on systolic blood pressure in each group
| Group | Systolic blood pressure (mmHg) | ||||
|---|---|---|---|---|---|
|
| |||||
| 0 week | 1 weeks | 3 weeks | 6 weeks | 8 weeks | |
| WKY | 118.42 ± 8.56 | 119.75 ± 7.93 | 117.50 ± 7.76 | 119.16 ± 6.82 | 120.08 ± 7.31 |
| SHR-Veh | 189.83 ± 10.39* | 192.58 ± 10.15* | 191.91 ± 11.02* | 194.00 ± 8.87* | 193.66 ± 7.10* |
| SHR-EPL30 | 190.17 ± 10.53* | 186.00 ± 9.80* | 183.42 ± 7.48* | 184.50 ± 8.21* | 184.16 ± 8.28* |
| SHR-EPL100 | 190.50 ± 10.26* | 182.83 ± 8.00* | 176.92 ± 8.24*,#,& | 171.67 ± 8.80*,#,& | 169.25 ± 7.90*,#,& |
Data are expressed as mean ± SD;
*
P < 0.05 versus WKY group at the same week;
#
P < 0.05 versus SHR-Veh group at the same week;
&
P < 0.05 versus SHR-EPL100 group at 0 week.
Significance was determined using one-way analysis of variance (one-way ANOVA) followed by Tukey’s post hoc test. SHR: spontaneous hypertensive rat. WKY: Wistar Kyoto rat.