Table 2.
The roles and mechanisms of HNF1A-AS1 in human cancers
| Disease type | Role | Cell lines | Functions | Related mechanisms | Refs |
|---|---|---|---|---|---|
| Gastric cancer | tumor promoter | HGC-27, MKN-45, AGS, NCI-N87, and BGC-823 | cell proliferation, migration, invasion, and 5-FU resistance | miR-30b-5p, EIF5A2, miR-30b-3p, PIK3CD, PI3K, AKT, miR-661, CDC34, | [26-28] |
| tumor suppressor | AGS, BGC-823, and MKN-45 | / | / | [24] | |
| Gastric cancer | tumor promoter | BGC-823, and MKN-45 | cell proliferation, migration, and invasion | EGR1, and miR-661 | [28] |
| liver cancer | tumor promoter | SMMC-7721, MHCC97L, Huh7 and HepG2 | cell proliferation, apoptosis, and autophagy | miR-30b-5p, ATG5, EZH2, NKD1, and p21 | [29-31] |
| Tumor suppressor | Huh-7, MHCC-97L, MHCC-97H, MHCC-LM3, SMMC-7721, and YY-8103 | cell proliferation, migration, and invasion | SHP-1 | [23] | |
| glioma | tumor promoter | U251, SHG-44, LN229, LN18, U87, T98G, and A172 | cell proliferation, apoptosis, migration, and invasion | EGR1, miR-22-3p, ENO1, MYC, miR-32-5p, SOX4, miR-363-3p, MAP2K4, and JNK | [32-34] |
| lung cancer | tumor promoter | A549, SPC-A1, PC9, H1299, H1563, H1437, H520, H2023, H1650, H1703, SK-MES-1, and Calu-1 | cell proliferation, apoptosis, migration, and invasion | miR-92a-3p, MAP2K4, miR-149-5p, Cdk6, miR-17-5p, and DNMT1 | [35-39] |
| colorectal cancer | tumor promoter | LoVo, SW620, HT-29, DLD-1, Ls-174T, HCT 116, and SW480 | cell proliferation, migration, invasion, and glycolysis | PBX3, OTX1, ERK, MAPK, miR-124, MYO6, Wnt, β-catenin, miRNA-34a, SIRT1, and p53 | [40-44] |
| colorectal cancer | tumor promoter | HT-29, HTC116, RKO, and SW480 | / | / | [88] |
| breast cancer | tumor promoter | MDA-MB-453, MDA-MB-231, MDA-MB-468, MDA-MB-436, MCF-7, BT-20, BT549, ZR-75-30, and HCC1937 | cell proliferation, apoptosis, migration, invasion, and TAM resistance | GATA1, miR-32-5p, RNF38, miR-363, SERTAD3, TGF-β, Smad, miRNA-20a-5p, and TRIM32 | [45-47] |
| bladder cancer | tumor promoter | T24, J82, UMUC3S, W780, SV-HUC-1, and 5637 | cell proliferation, apoptosis, migration, and invasion | miR-101-3p, and Bcl-2 | [48-50] |
| osteosarcoma | tumor promoter | U2OS, SAOS-2, 143B, HOS, SOSP-9607, and MG63 | cell proliferation, apoptosis, migration, and invasion | miR-32-5p, HMGB1, Wnt, and β-catenin | [51-53] |
| cervical cancer | tumor promoter | HeLa/DDP | cell proliferation, apoptosis, and cisplatin resistance | / | [56,57] |
| esophageal adenocarcinoma | tumor promoter | jhu-esoad1, FLO-1, SKGT-4, and OE33 | cell proliferation, and migration | H19, chromatin and nucleosome assembly | [25] |
| hemangioma | tumor promoter | endothelial cells | cell proliferation, migration, and invasion | / | [54] |
| oral squamous cell carcinoma | tumor promoter | CAL-27, HN5, SCC-15, SCC-9, and Tca8113 | cell proliferation, apoptosis, migration, and invasion | STAT3, and Notch | [55] |
| laryngeal squamous cell carcinoma | Tumor suppressor | TU-177, AMC-HN-8, TU-686, and 293T | cell proliferation, migration, and invasion | / | [22] |
| gastroenteropancreatic neuroendocrine neoplasms | Tumor suppressor | QGP-1, and STC-1 | cell proliferation, migration, and invasion | TCF3, and Oncostatin M | [58] |