Table 3. Effects of 1–4, 6, 8, and 9 against Leishmania Promastigotes and Axenic Amastigotes Expressed as a Percent of Inhibition and against Intramacrophagic Amastigotes (HCA).
| percentage of inhibition |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
L. amazonensis promastigotes |
L. donovani promastigotes |
L. donovani axenic amastigotes |
|||||||||
| lab code | compd | 20 μM | 4 μM | 0.8 μM | 20 μM | 4 μM | 0.8 μM | 20 μM | 4 μM | 0.8 μM | HCA |
| MC1742 | 1 | 2.1 ± 3.2 | NA | NA | NA | NA | NA | 29.0 ± 14.0 | NA | NA | toxic |
| MC2129 | 2 | 83.3 ± 1.8 | 11.3 ± 1.7 | NA | 74.8 ± 2.5 | 2.5 ± 1.4 | 1.1 ± 2 | 60.2 ± 1.4 | 7.8 ± 1.1 | 16.4 ± 18.6 | toxic |
| MC1575 | 3 | 9.1 ± 6.3 | NA | NA | 6.8 ± 1.8 | 1.7 ± 1.5 | 3.8 ± 3.4 | 74.9 ± 1.3 | 50.8 ± 2.4 | 4.9 ± 4.9 | inactive |
| MC2780 | 4 | 97.9 ± 0.4 | 95.7 ± 0.3 | 10.5 ± 2.9 | 95.9 ± 0.3 | NA | NA | 93.6 ± 0.4 | 61.4 ± 4.3 | 39.5 ± 2.0 | toxic |
| MC3031 | 6 | 60.1 ± 1.7 | 9.2 ± 3.4 | NA | 8.6 ± 1.3 | 6.9 ± 8.7 | 7.9 ± 7.5 | 39.6 ± 5.5 | 0.1 ± 0.8 | 39.9 ± 2.1 | toxic |
| MC2392 | 8 | NA | 8.3 ± 3.4 | 8.1 ± 2.1 | 6.3 ± 1.7 | NA | 2.3 ± 1.4 | 41.8 ± 1.4 | 5.8 ± 2.5 | 4.3 ± 1.1 | weakly active |
| MS-275 | 9 | NA | NA | NA | NA | NA | NA | 28.9 ± 0.9 | 2.9 ± 10.1 | 6.7 ± 3.8 | toxic |