Table 5. Effect of 17–20 in NTS.
percentage
of NTS activity, 72 h |
|||||
---|---|---|---|---|---|
lab code | compd | 20 μM | 10 μM | 1 μM | IC50 (μM) |
MC2776 | 17 | 100.0 ± 0.0 | 100.0 ± 0.0 | 28.0 ± 0.0 | 1.23 |
MC2779 | 18 | 100.0 ± 0.0 | 100.0 ± 0.0 | 26.0 ± 1.0 | 1.26 |
MC2778 | 19 | 100.0 ± 0.0 | 100.0 ± 0.0 | 24.0 ± 0.0 | 1.29 |
MC2783 | 20 | 100.0 ± 0.0 | 100.0 ± 0.0 | 22.0 ± 1.0 | 1.32 |