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. 2022 Jun 28;8(7):1303–1315. doi: 10.1021/acsinfecdis.2c00075

Figure 4.

Figure 4

Amount of PI 16:0_19:0 in PBMCs of TB patients are indicative of disease status. (A) Concentration of PI 16:0_19:0 in PBMCs of 39 healthy individuals (n = 1 negative for PI 16:0_19:0) and 23 TB patients at therapy start (t0). The median is indicated with a black bar. Statistical significance was examined with the Mann–Whitney test (individual data from patients and healthy controls are listed in data files S3 and S4). (B) PI 16:0_19:0 concentration at therapy start (t0) and at therapy end (tE) for 13 patients with the WHO-defined outcome “therapy completed”. (C) Comparison of PI 16:0_19:0 concentration for nine patients at therapy start (t0) and therapy end (tE) that further fulfilled the outcome criteria “cured” following the TBnet criteria. Statistical examination for (B,C) was performed with a Wilcoxon matched-pair signed rank test. All statistical tests were performed with GraphPad Prism 8.4.3. Data for comparison of TB patients at t0 and tE according to the outcome criteria definition are listed in data file S5.