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Compound 16 shows superior cellular growth inhibition activity in a panel of TNBC cells compared to the EZH2 inhibitor EPZ-6438 and compound 17. BT549 (A), MDA-MB-468 (B), SUM159 (C), and MDA-MB-453 (D) cells were treated with serial dilution (starting from 10 μM, with 2-fold dilution) of 16, EPZ-6438, YM281, or negative control 17 for 5 days. Cell viability was determined using a WST-8 assay. GI50 results shown are the mean values ± SD from three independent experiments.
