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Compound 16 displays superior EZH2 degradation compared to YM281 in TNBC cells. BT549 (A), MDA-MB-468 (B), SUM159 (C), and MDA-MB-453 (D) cells were treated with DMSO, 16, or YM281 at indicated concentrations for 48 h. Cell lysates were analyzed by Western blotting to examine the EZH2 protein level with β-actin or H3 used as the loading control. Results shown are representative of at least two independent experiments.
