Table 6. Compound 18 and GLPG1972 PK Results from Rat MIA PD Biomarker and Rat MMT Studies.

		rat MIA PD Biomarker		rat MMT
cmpd	dose (po, mpk, BID)	day 3 plasma AUC (h × ng/mL) (n = 5) mean (95% CI)	day 7 cartilage concentration @ 3 h (ng/g) (n = 5) mean ± SEM	day 1 plasma AUC (h × ng/mL) (n = 4) mean (95% CI)	day 20 plasma AUC (h × ng/mL) (n = 4) mean (95% CI)	day 21 cartilage AUC (h × ng/g) (n = 3) mean (95% CI)
18	25	(50 507–77 431)	1973 ± 346	(52 853–83 360)	(57 988–72 933)	(11 743–20 028)
18	50	(116 997–175 491)	4618 ± 774	(100 018–205 838)	(165 234–205 017)	(20 987–69 494)
18	75	(112 578–207 374)	4177 ± 1251
GLPG1972	75			(16 852–25 966)	(18 260–26 477)	(3641–18 515)