Table 3.
Stage 2 mega-analysis and replication results.
| Stage 2 mega-analysis |
ADNI |
ACT |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP | CHR | BP | Gene | OR [95% CI] | P | OR [95% CI] | P | OR [95% CI] | P |
| rs61776730 | 1 | 71,057,739 | BC041441 | 1.46 [1.24–1.72] | 7.3e-06 | – | – | – | – |
| rs2418491 | 2 | 59,535,434 | FLJ30838 | 1.24 [1.13–1.37] | 7.6e-06 | – | – | – | – |
| rs13082422 | 3 | 22,338,009 | ZNF385D | 1.22 [1.12–1.34] | 8.1e-06 | – | – | – | – |
| rs3774902 | 4 | 23,890,782 | PPARGC1A | 1.55 [1.27–1.88] | 9.7e-06 | – | – | – | – |
| rs7675509 | 4 | 161,518,462 | FSTL5 | 1.24 [1.13–1.36] | 7.2e-06 | – | – | – | – |
| rs10050232 | 4 | 168,333,572 | SPOCK3 | 1.25 [1.14–1.38] | 7.0e-06 | – | – | – | – |
| rs6898408 | 5 | 58,406,648 | PDE4D | 1.23 [1.12–1.35] | 9.3e-06 | – | – | – | – |
| rs4370294 | 5 | 177,510,515 | N4BP3 | 1.24 [1.13–1.35] | 5.3e-06 | – | – | – | – |
| rs2603462 | 6 | 81,418,667 | BCKDHB | 1.34 [1.2–1.5] | 4.0e-07 | 4.75 [1.42–15.91] | 0.012 | 0.77 [0.52–1.13] | 0.18 |
| rs7902929 | 10 | 107,237,532 | SORCS3 | 1.58 [1.33–1.87] | 1.8e-07 | 26.49 [2.07–338.8] | 0.012 | 0.81 [0.47–1.4] | 0.45 |
| rs61944465 | 13 | 27,272,704 | WASF3 | 1.29 [1.16–1.44] | 2.3e-06 | – | – | – | – |
Note: A1 set so that Stage 2 mega-analysis OR >= 1.
SNP: single nucleotide polymorphism; CHR: Chromosome; BP: base pair; Gene: closest protein-coding gene; A1/A2: effect/non-effect allele; OR: odds ratio; 95% CI: 95% confidence interval.