Table 1.
Participant physiological parameters at rest. Values are population mean ± SD.
| Parameter | HC (n = 51) | PD Medicated (n = 34) | PD Un-medicated (n = 34) | P-value - HC vs. medicated | P-value - HC vs. unmedicated |
|---|---|---|---|---|---|
| Mean CBFV (cm.s-1) | 49.7 ± 13.0 | 47.7 ± 9.6 | 48.6 ± 9.6 | 0.45 | 0.70 |
| MAP (mmHg) | 91.7 ± 10.0 | 90.9 ± 12.9 | 94.1 ± 13.1 | 0.73 | 0.35 |
| Heart rate (bpm) | 63.2 ± 9.1 | 61.8 ± 9.9 | 62.4 ± 9.4 | 0.48 | 0.68 |
| End-tidal CO2 (mmHg) | 38.2 ± 4.3 | 37.3 ± 3.9 | 37.7 ± 4.0a | 0.37 | 0.63 |
HC: healthy controls; PD-medicated: Parkinson’s disease patients with medication ON; PD-unmedicated: Parkinson’s patients with medication OFF; Mean CBFV: cerebral blood flow velocity averaged across hemispheres. MAP: mean arterial pressure.
P-value; unpaired t-tests.
aEtCO2 data from two participants excluded due to unreliable capnography trace.