Table III.
Prevalence odds ratios (PORs) and 95% confidence intervals (95% CI) of cancer prior to bullous pemphigoid (BP) diagnosis
| Cancer types (ICD-7 codes) | Observed no. of cancers |
POR overall (95% CI) | POR ≤ 1 year before BP 95% CI) | POR > 1 year before BP (95% CI) | |
|---|---|---|---|---|---|
| BP | Control cohort | ||||
| All cancers (140–204) | 1,298 | 3,958 | 1.0 (0.9–1.0) | 1.1 (0.9–1.3) | 1.0 (0.9–1.0) |
| Buccal (140–148) | 21 | 58 | 1.1 (0.7–1.8) | 0.4 (0.0–3.5) | 1.2 (0.7–2.0) |
| Digestive tract (150–159) | 201 | 595 | 1.0 (0.9–1.2) | 1.4 (0.9–2.3) | 1.0 (0.8–1.1) |
| Respiratory (160–164) | 25 | 75 | 1.0 (0.6–1.6) | 1.0 (0.3–3.1) | 1.0 (0.6–1.6) |
| Breast (170) | 168 | 487 | 1.0 (0.9–1.2) | 1.4 (0.8–2.7) | 1.0 (0.8–1.2) |
| Female genital (171–176) | 96 | 256 | 1.1 (0.9–1.4) | 1.2 (0.2–6.2) | 1.1 (0.9–1.4) |
| Male genital (177–179) | 255 | 832 | 0.9 (0.8–1.0) | 0.4 (0.2–0.8) | 1.0 (0.8–1.1) |
| Kidney and bladder (180–181) | 89 | 247 | 1.1 (0.8–1.4) | 1.00 (0.5–2.1) | 1.1 (0.8–1.4) |
| Melanoma (190) | 87 | 256 | 1.0 (0.8–1.3) | 1.1 (0.5–2.4) | 1.0 (0.8–1.3) |
| Squamous cell carcinoma of the skin (191) | 228 | 795 | 0.8 (0.7–1.0) | 1.1 (0.7–1.6) | 0.8 (0.7–1.0) |
| Eye and brain (192–193) | 26 | 57 | 1.4 (0.9–2.2) | 1.5 (0.1–16.5) | 1.4 (0.8–2.2) |
| Thyroid and endocrine (194–195) | 29 | 74 | 1.2 (0.8–1.8) | 2.0 (0.3–11.9) | 1.1 (0.7–1.8) |
| Connective tissue (196–197) | 7 | 25 | 0.8 (0.4–1.9) | 1.00 (1.00–1.00) | 0.9 (0.4–2.0) |
| Haematopoietic (200–209) | 34 | 98 | 1.0 (0.7–1.5) | 2.2 (0.9–5.3) | 0.9 (0.6–1.4) |
| Lymphomas (200–202, 204.1) | 25 | 80 | 0.9 (0.6–1.5) | 1.9 (0.7–4.9) | 0.8 (0.5–1.3) |
| Other cancers | 7 | 23 | 0.9 (0.4–2.1) | 1.5 (0.8–8.2) | 0.8 (0.3–2.1) |
Bold: 95% confidence interval (95% CI) does not include 1.00.
ICD-7: International Classification of Diseases, seventh revision.