Fig. 2.

(A) Intensity of sensation (numerical rating scale (NRS) 0–10) recorded upon single half sine wave pulses of 500-ms duration and up to 1-mA intensity delivered to non-affected control skin (left panel, open symbols) and in the eczema-affected skin (right panel, solid symbols). Itch was recorded in 9 patients (squares) and pain (no itch) in 17 patients (circles). The intensity of sensation increased current intensity dependently, but did not differ significantly between patient groups (itch vs no itch) or investigated skin sites (control vs eczema). Error bars indicate standard error of the mean (SEM). (B) Intensity of sensation (NRS 0–10) recorded upon 2.5-s 4-Hz sinusoidal stimuli (10 pulses) delivered at intensities of 0.025–0.4 mA to non-affected control skin (left panel, open symbols) and in the eczema-affected skin (right panel, solid symbols). Three patients responded with itch from in the eczema-affected skin (squares) and n = 22 patients reported pain (no itch, circles). The intensity of sensation increased current intensity dependently, but was not significantly different between the patient groups (itch vs no itch) or the investigated skin site (control vs eczema). Error bars indicate SEM.