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. Author manuscript; available in PMC: 2022 Jul 12.
Published in final edited form as: Adv Funct Mater. 2021 Mar 31;31(24):2011103. doi: 10.1002/adfm.202011103

Figure 9.

Figure 9.

(a) Schematic for charge-reversing PIC micelle strategy for pDNA delivery, wherein the anionic ternary polyplex reverses to cationic under acidic pH condition in endosome causing endosomal disruption; (b) Structure of cationic pAsp(DET), charge-reversing pAsp(DET-Aco), and non-charge reversing control pAsp(EDA-Suc) polymers; (c) Zeta potential measurements to observe charge conversion in pDNA/pAsp(DET)/pAsp(DET-Aco), solid sphere: at pH 7.4, dark sphere: at pH 5.5 (reproduced with permission from reference 83, Copyright 2008 Wiley-VCH Verlag GmbH & Co.); (d) Utilization of phenylboronic acid-diol interaction for siRNA encapsulation in PIC micelles and its ATP-responsive release (reproduced with permission from reference 85, Copyright 2012 Wiley-VCH Verlag GmbH & Co.).