Table 2.
The association between hormones and S-Klotho concentration among the U.S. males in NHANES 2011–2016
| Number of Subjects | Unadjusted model | Adjusted modela | |||
|---|---|---|---|---|---|
| β, (95% CI) | p values | β, (95% CI) | p values | ||
| TT | 3749 | 0.133 (0.056, 0.210) | 0.001 | 0.165 (0.065,0.266) | 0.004 |
| E2 | 2526 | 1.963 (0.388, 3.538) | 0.021 | 2.232 (0.588, 3.876) | 0.032 |
| SHBG | 2356 | 1.235 (0.627, 1.843) | < 0.001 | 2.013 (1.173, 2.583) | 0.002 |
| T/E2 ratio | 2525 | 220.419 (-443.164, 884.002) | 0.520 | 455.345 (-398.496, 1309.186) | 0.331 |
| TD | 3749 | -13.794 (-34.003, 6.416) | 0.188 | -18.062 (-40.968, 4.843) | 0.135 |
Abbreviation: NHANES The National Health and Nutrition Examination Survey, CI Confidence interval, TT Total testosterone, E2 Estradiol, SHBG The sex hormone-binding globulin, T/E2 ratio The ratio of testosterone to estradiol, TD Testosterone deficiency
a The model was fully adjusted by age, race, education level, marital status, family income-poverty ratio, BMI, time of venipuncture, CAD score, smoking status, alcohol consumption, and physical activity