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SAM reverted effect of obesity induced therapy resistance: SAM was increased in Lean≫Obese FMT animals in fecal (a) sample. SAM was decreased in Obese animals (b). Schema showing experimental set up SAM treatment in high fat diet fed, pancreatic tumor bearing mice (c). SAM decreased tumor volume (d) and weight (e). Treatment with SAM also decreased collagen (f) and Ki67+ cells (g).
