Figure 6.

Queuosine mediated chemoresistance by upregulating PRDX1: Treatment of pancreatic cancer cell SU86.86 increased expression of PRDX1 as seen in oxidative stress PCR array analysis (a). Western blot showing upregulation of PRDX1 protein after treatment with Pre-Q (b). Silencing PRDX1 using siRNA presented Pre-Q induced resistance in MIA-PACA2 cells (c). IHC of lean and obese tumor bearing mice show upregulation of PRDX1 in obese mice (d). FMT of obese≫lean mice increased PRDX1 expression in these animals.