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. 2022 Jul 12;12(31):19764–19855. doi: 10.1039/d2ra03081k

Chemical structures of pyrazole derivatives 1–9 and their IC50 values against cholinesterase enzymes.

Compound no. Chemical structure IC50 values (µM) References
AChE BChE
1 graphic file with name d2ra03081k-u1.jpg 44.66–78.34 nM 50.36–88.36 nM 165
2 graphic file with name d2ra03081k-u2.jpg 0.20 166
3 graphic file with name d2ra03081k-u3.jpg 0.46 166
4 graphic file with name d2ra03081k-u4.jpg 0.42 166
5 graphic file with name d2ra03081k-u5.jpg 506–1022 nM 167
6 graphic file with name d2ra03081k-u6.jpg 506–1022 nM 167
7 graphic file with name d2ra03081k-u7.jpg 1.937 1.166 168
8 graphic file with name d2ra03081k-u8.jpg 0.055 169
9 graphic file with name d2ra03081k-u9.jpg 0.017 169