Chemical structures of quinoline derivatives 221–248 and their IC50 values against cholinesterase enzymes.
| Compound no. | Chemical structure | IC50 values (µM) | References | |
|---|---|---|---|---|
| AChE | BChE | |||
| 221 |
|
1.07 | 4.59 | 258 |
| 222 |
|
10.80 | 4.70 | 258 |
| 223 |
|
5.83 | 14.00 | 258 |
| 224 |
|
0.49 | 5.91 | 258 |
| 225 |
|
2.77 | 717 | 258 |
| 226 |
|
5.20 | 699 | 258 |
| 227 |
|
5.48 | 744 | 258 |
| 228 |
|
16.17 | — | 259 |
| 229 |
|
0.56 | 2.3 | 260 |
| 230 |
|
0.069 | 1.35 | 261 |
| 231 |
|
4.36 | — | 262 |
| 232 |
|
7.10 | — | 262 |
| 233 |
|
0.032 | 0.90 | 263 |
| 234 |
|
2.99 | 0.11 | 263 |
| 235 |
|
0.62 | 0.10 | 264 |
| 236 |
|
32.06 | — | 265 |
| 237 |
|
10.24 | — | 266 |
| 238 |
|
11.89 | — | 266 |
| 239 |
|
17.74 | — | 266 |
| 240 |
|
28.42 | — | 267 |
| 241 |
|
38.39 | — | 267 |
| 242 |
|
52.55 | — | 267 |
| 243 |
|
55.23 | — | 267 |
| 244 |
|
0.65 | 1.32 | 268 |
| 245 |
|
0.85 | 1.65 | 268 |
| 246 |
|
0.92 | 1.91 | 268 |
| 247 |
|
0.71 | 0.04 | 269 |
| 248 |
|
1.01 | 0.03 | 269 |