Chemical structures of pyrimidine derivatives 249–262 and their IC50 values against cholinesterase enzymes.
| Compound no. | Chemical structure | IC50 values (µM) | References | |
|---|---|---|---|---|
| AChE | BChE | |||
| 249 |
|
5.5 | 56.9 | 270 |
| 250 |
|
8.7 | 26.4 | 270 |
| 251 |
|
7.9 | 2.2 | 270 |
| 252 |
|
0.17 | 2.37 | 271 |
| 253 |
|
0.39 | 5.69 | 271 |
| 254 |
|
2.01 | — | 271 |
| 255 |
|
— | 30 | 271 |
| 256 |
|
2.01 | — | 271 |
| 257 |
|
15.01 | — | 271 |
| 258 |
|
143.73 | 144.81 | 272 |
| 259 |
|
2.84 | — | 273 |
| 260 |
|
2.19 | — | 273 |
| 261 |
|
47.33 nM | 159.43 nM | 274 |
| 262 |
|
51.36 nM | 153.3 nM | 274 |