Chemical structures of different N, O and S based heterocycles 292–323 and their IC50 values against cholinesterase enzymes.
| Compound no. | Chemical structure | IC50 values (µM) | References | |
|---|---|---|---|---|
| AChE | BChE | |||
| 292 |
|
210.56 | — | 285 |
| 293 |
|
70.470 | — | 285 |
| 294 |
|
1.26 | — | 19 |
| 295 |
|
0.98 | 1.02 | 19 |
| 296 |
|
6.39 | — | 19 |
| 297 |
|
5.27 | — | 19 |
| 298 |
|
2.05 | 5.42 | 18 |
| 299 |
|
10.2 | 3.12 | 18 |
| 300 |
|
18.52 | 25.51 | 18 |
| 301 |
|
2.01 | 1.40 | 13 |
| 302 |
|
0.08 | 0.12 | 13 |
| 303 |
|
0.07 | 0.15 | 13 |
| 304 |
|
3.63 | — | 286 |
| 305 |
|
1.10 | — | 286 |
| 306 |
|
324 nM | — | 287 |
| 307 |
|
226 nM | — | 287 |
| 308 |
|
0.09 | 27.91 | 288 |
| 309 |
|
0.103 | — | 289 |
| 310 |
|
0.05 | 0.09 | 21 |
| 311 |
|
0.07 | — | 21 |
| 312 |
|
0.08 | — | 21 |
| 313 |
|
1.29 µmol L−1 | — | 290 |
| 314 |
|
9.68 | 11.59 | 291 |
| 315 |
|
15.8 | — | 291 |
| 316 |
|
0.077 | — | 292 |
| 317 |
|
40.64 | — | 292 |
| 318 |
|
14.91 | — | 292 |
| 319 |
|
0.12 | — | 293 |
| 320 |
|
0.1761 | — | 294 |
| 321 |
|
3.63 | 56.01 | 295 |
| 322 |
|
52.50 | — | 296 |
| 323 |
|
0.42 | — | 297 |