Chemical structures of imidazole derivatives 10–24 and their IC50 values against cholinesterase enzymes.
Compound no. | Chemical structure | IC50 values (µM) | References | |
---|---|---|---|---|
AChE | BChE | |||
10 | 177.69 | 90.20 | 170 | |
11 | 274.69 | 101.20 | 170 | |
12 | 5.12 | 8.63 | 171 | |
13 | 9.74 | 6.59 | 171 | |
14 | 16.38 | 11.44 | 171 | |
15 | 19.57 | 18.08 | 171 | |
16 | 0.33 | — | 172 | |
17 | 0.324 | — | 173 | |
18 | 17.3 nM | 41.67 nM | 174 | |
19 | 17.3 nM | 27.02 nM | 174 | |
20 | 17.32 nM | 64.28 nM | 174 | |
21 | 2.02 | 12.40 | 175 | |
22 | 2.05 | 11.45 | 175 | |
23 | 11.8 | — | 176 | |
24 | 8.77 | — | 177 |