Chemical structures of oxadiazole derivatives 25–84 and their IC₅₀ values against cholinesterase enzymes.

Compound no.	Chemical structure	IC50 values (µM)		References
		AChE	BChE
25		135	132	178
26		254	138	178
27		301	74	178
28		298	114	178
29		>400	80	178
30		101	152	178
31		24.89	—	179
32		13.72	—	179
33		37.65	—	179
34		19.63	—	179
35		11.55	—	180
36		11.55–77.79	—	180
37		11.55–77.79	—	180
38		74.7	64.3	181
39		129.6	69.6	181
40		107.9	66.1	181
41		70.8	82.2	181
42		17.5	72.7	181
43		6.07	2.98	182
44		7.12	1.45	182
45		9.18	0.15	182
46		34.61	—	183
47		40.21	—	183
48		45.11	—	183
49		33.31	—	183
50		62.54	—	184
51		47.69	—	184
52		28.54	—	184
53		7.21	—	185
54		5.76	—	185
55		3.64	—	185
56		7.62	—	185
57		9.49	8.17	186
58		7.58	9.56	186
59		5.69	—	187
60		5.91	—	187
61		6.52	—	187
62		1.098	—	188
63		0.054	0.787	189
64		0.055	0.186	190
65		0.086	0.143	190
66		0.144	0.220	190
67		0.119	0.751	190
68		7.19	4.61	191
69		9.45	5.28	191
70		0.51–69.44	—	192
71		0.51–69.44	—	192
72		0.16	3.12	193
73		1.10	1.94	193
74		1.59	1.86	193
75		1.82	2.76	193
76		2.17	5.23	193
77		0.068	0.218	193
78		0.092	0.163	193
79		0.33	0.73	193
80		0.22	0.91	193
81		0.28	0.29	193
82		0.19	0.42	193
83		—	0.463	194
84		—	0.359	194