Chemical structures of triazole derivatives 114–148 and their IC50 values against cholinesterase enzymes.
Compound no. | Chemical structure | IC50 values (µM) | References | |
---|---|---|---|---|
AChE | BChE | |||
114 | >100 µM mL−1 | — | 206 | |
115 | 7.31 µM mL−1 | — | 206 | |
116 | 4.52 | — | 207 | |
117 | 5.31 | — | 207 | |
118 | 114 | — | 208 | |
119 | 104 | — | 208 | |
120 | >350 | 5.98 | 209 | |
121 | 4.89 | 3.61 | 210 | |
122 | 10 | 6.06 | 210 | |
123 | 11.07 | 61.13 | 210 | |
124 | 19.59 | 66.68 | 210 | |
125 | 1.46 µg mL−1 | — | 211 | |
126 | 0.521 | — | 212 | |
127 | 0.055 | — | 212 | |
128 | 27 | — | 213 | |
129 | 6 | — | 213 | |
130 | — | 0.42 | 214 | |
131 | 0.0876 | — | 215 | |
132 | 0.0574 | — | 215 | |
133 | — | 1.80 | 216 | |
134 | 0.059 | — | 217 | |
135 | 6.4 | — | 218 | |
136 | 7.9 | — | 218 | |
137 | 7.3 | 68.6 | 219 | |
138 | 2.06 | — | 220 | |
139 | 0.23 | — | 220 | |
140 | 1.10 | — | 220 | |
141 | 5.41 | 7.52 | 221 | |
142 | 13.75 | — | 221 | |
143 | 26.30 | — | 222 | |
144 | 21.71 | >100 | 223 | |
145 | 0.259 | — | 224 | |
146 | 0.372 | — | 224 | |
147 | 0.327 | — | 224 | |
148 | — | 4.78 | 225 |