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. 2022 Jul 12;12(31):19764–19855. doi: 10.1039/d2ra03081k

Chemical structures of piperidine derivatives 182–202 and their IC50 values against cholinesterase enzymes.

Compound no. Chemical structure IC50 values (µM) References
AChE BChE
182 graphic file with name d2ra03081k-u182.jpg 186 nM 244
183 graphic file with name d2ra03081k-u183.jpg 192 nM 244
184 graphic file with name d2ra03081k-u184.jpg 200 nM 244
185 graphic file with name d2ra03081k-u185.jpg 120 nM 244
186 graphic file with name d2ra03081k-u186.jpg 325 nM 244
187 graphic file with name d2ra03081k-u187.jpg 362 nM 244
188 graphic file with name d2ra03081k-u188.jpg 157 245
189 graphic file with name d2ra03081k-u189.jpg 219 245
190 graphic file with name d2ra03081k-u190.jpg 145 245
191 graphic file with name d2ra03081k-u191.jpg 0.71 246
192 graphic file with name d2ra03081k-u192.jpg 0.26 246
193 graphic file with name d2ra03081k-u193.jpg 0.88 246
194 graphic file with name d2ra03081k-u194.jpg 0.05 246
195 graphic file with name d2ra03081k-u195.jpg 0.02 246
196 graphic file with name d2ra03081k-u196.jpg 0.13 246
197 graphic file with name d2ra03081k-u197.jpg 0.17 246
198 graphic file with name d2ra03081k-u198.jpg 0.01 246
199 graphic file with name d2ra03081k-u199.jpg 6.83 nM 247
200 graphic file with name d2ra03081k-u200.jpg 2.13 nM 247
201 graphic file with name d2ra03081k-u201.jpg 6.62 13.78 248
202 graphic file with name d2ra03081k-u202.jpg 35.30 249