Chemical structures of piperidine derivatives 182–202 and their IC50 values against cholinesterase enzymes.
Compound no. | Chemical structure | IC50 values (µM) | References | |
---|---|---|---|---|
AChE | BChE | |||
182 | 186 nM | — | 244 | |
183 | 192 nM | — | 244 | |
184 | 200 nM | — | 244 | |
185 | 120 nM | — | 244 | |
186 | 325 nM | — | 244 | |
187 | 362 nM | — | 244 | |
188 | 157 | — | 245 | |
189 | 219 | — | 245 | |
190 | 145 | — | 245 | |
191 | 0.71 | — | 246 | |
192 | 0.26 | — | 246 | |
193 | 0.88 | — | 246 | |
194 | 0.05 | — | 246 | |
195 | 0.02 | — | 246 | |
196 | 0.13 | — | 246 | |
197 | 0.17 | — | 246 | |
198 | 0.01 | — | 246 | |
199 | 6.83 nM | — | 247 | |
200 | 2.13 nM | — | 247 | |
201 | 6.62 | 13.78 | 248 | |
202 | — | 35.30 | 249 |