Chemical structures of piperazine derivatives 203–220 and their IC50 values against cholinesterase enzymes.
| Compound no. | Chemical structure | IC50 values (µM) | References | |
|---|---|---|---|---|
| AChE | BChE | |||
| 203 |
|
0.11 | — | 250 |
| 204 |
|
2 nM | — | 251 |
| 205 |
|
260 nM | — | 251 |
| 206 |
|
29.5 | — | 252 |
| 207 |
|
0.092 | — | 253 |
| 208 |
|
51.66 | — | 254 |
| 209 |
|
79.12 | — | 254 |
| 210 |
|
0.6 | — | 255 |
| 211 |
|
0.5 | — | 255 |
| 212 |
|
0.4 | — | 255 |
| 213 |
|
0.3 | — | 255 |
| 214 |
|
0.2 | — | 255 |
| 215 |
|
0.268 | — | 256 |
| 216 |
|
0.286 | — | 256 |
| 217 |
|
289.61 | — | 257 |
| 218 |
|
252.36 | — | 257 |
| 219 |
|
412.71 | — | 257 |
| 220 |
|
54.81 | — | 257 |