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. 2022 Jul 12;17(7):e0271308. doi: 10.1371/journal.pone.0271308

Fig 5. Comparison of LCA detoxification activities.

Fig 5

DKO mice at 20 weeks of age, with (+) or without (-) UDCA treatment, were compared. (A) Proposed metabolic pathways for LCA in mice. (B) Hepatic concentrations of LCA-3S and TLCA-3S and mRNA expression levels of Sult2a1. (C) Hepatic concentrations of HDCAs (HDCA + THDCA) and MDCAs (MDCA + TMDCA) and mRNA expression levels of Cyp3a11. (D) Hepatic microsomal enzyme activities that catalyze 6α-, 6β-, and 7α-hydroxylations of TLCA. Each column and error bar represents the mean and SEM. *P < 0.05 and **P < 0.01 were considered statistically significantly different by the Tukey-Kramer test.