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. 2022 Jul 12;17(7):e0271308. doi: 10.1371/journal.pone.0271308

Fig 6. Effects of UDCA treatment on hepatic cholesterol and BA metabolism.

Fig 6

DKO mice at 20 weeks of age, with (+) or without (-) UDCA treatment were compared. (A) Hepatic mRNA expression levels of nuclear receptors and their target genes. (B) Hepatic concentrations of cholesterol and oxysterols. CHOL, cholesterol; HC, hydroxycholesterol; EC, epoxycholesterol. (C) Hepatic mRNA expression levels of the key enzyme in the cholesterol biosynthetic pathway and serum sterol concentrations associated with cholesterol metabolism. (D) Hepatic activities and mRNA expression levels of key enzymes in the BA biosynthetic pathways and serum concentrations of FGF15. Each column and error bar represents the mean and SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 were considered statistically significantly different by the Tukey-Kramer test.