Table 1. Effects of UDCA administration on the fertility of DKO mice.

Parameter	Groups	With UDCA	Without UDCA	P-value
Pregnancy / Mating	Mating	n = 75	n = 10	NS
	Pregnancy	53 a (70.7%)	8 (80.0%)
	No pregnancy	22 (29.3%)	2 (20.0%)
Delivery / Pregnancy	Pregnancy	n = 43a	n = 8	< 0.005
	Normal delivery	43 (100%)	5 (62.5%)
	Abnormal deliveryb	0 (0%)	3 (37.5%)
Number of pups / Litter	Normal delivery	n = 43	n = 5	—
	Number of pups	226	26
	Per litter	5.3	5.2

^aTen pregnant individuals were euthanized for population control.

^bAbnormal delivery includes miscarriage and preterm birth. Fisher exact tests were used to assess the association of UDCA administration with pregnancy and delivery rates. NS, not significant.