Fig 1. Amino acid changes acquired in Env during pathogenic SIVmac239ΔGY infection.

Amino acid (a.a.) sequences of SIVmac239 and ΔGY Env are shown indicating the membrane spanning domain (MSD), the predicted start of the cytoplasmic domain, and approximate start sites for the second exons of tat and rev in overlapping reading frames. Below (in red) are a.a. changes previously reported in RM [32] and PTM [18] that failed to control ΔGY and progressed to disease. YxxØ motifs created by ΔQTH mutations are underlined (see S1 Fig for nt sequences).