Table 3.
Meta-analysis of the association between HIF-1α expression and clinicopathological characteristics
| Stratified analysis | No. of studies |
No. of patients |
Test of association | Test of heterogeneity | |||
|---|---|---|---|---|---|---|---|
| Pooled OR (95% CI) | p-value | I2 (%) | P-value | Model | |||
| Gender (male vs. female) | 32 | 4995 | 0.94 (0.70-1.25) | 0.659 | 72.72 | <0.001 | R |
| Age (≥55 vs. <55) | 28 | 4472 | 0.93 (0.78-1.10) | 0.382 | 35.9 | 0.03 | R |
| Tumor size (large vs. small) | 21 | 3571 | 1.39 (1.07-1.82) | 0.022 | 68.65 | <0.001 | R |
| LNM (yes vs. no) | 33 | 3822 | 1.87 (1.49-2.35) | <0.001 | 58.62 | <0.001 | R |
| DM(yes vs. no) | 16 | 2353 | 2.60 (1.50-4.52) | <0.001 | 76.38 | <0.001 | R |
| Tumor stage (III+IV vs. I+II) | 28 | 4462 | 1.80 (1.44-2.26) | <0.001 | 61.65 | <0.001 | R |