Table 3.
The association of variables of interest with specific CNS-directed MBM treatments as first treatment.
| First Treatment of Shunt | First Treatment of Craniotomy | First Treatment of SRS | First Treatment of WBRT | ||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariable | Multivariable* | Univariable | Multivariable* | Univariable | Multivariable* | Univariable | Multivariable* | ||||||||||||||||||||||||||||||||
| Variable of Interest | N (%) | N events (%) | Cause-Specific HR | 95% CI | P-value | Cause-Specific HR | 95% CI | P-value | N (%) | N events (%) | Cause-Specific HR | 95% CI | P-value | Cause-Specific HR | 95% CI | P-value | N (%) | N events (%) | Cause-Specific HR | 95% CI | P-value | Cause-Specific HR | 95% CI | P-value | N (%) | N events (%) | Cause-Specific HR | 95% CI | P-value | Cause-Specific HR | 95% CI | P-value | |||||||
| Number of BM | 425 (100) | 10 (100) | 0.73 | 0.48–1.09 | 0.13 | 425 (100) | 137 (100) | 0.87 | 0.81–0.92 | <0.0001 | 0.87 | 0.81–0.93 | <0.0001 | 425 (100) | 138 (100) | 0.97 | 0.94–1.00 | 0.03 | 0.97 | 0.94–1.00 | 0.04 | 425 (100) | 118 (100) | 1.04 | 1.03–1.06 | <0.0001 | 1.04 | 1.03–1.06 | <0.0001 | ||||||||||
| Dominant BM Size | 425 (100) | 10 (100) | 1.71 | 1.32–2.20 | <0.0001 | 1.72 | 1.22–2.42 | 0.002 | 425 (100) | 137 (100) | 1.57 | 1.46–1.70 | <0.0001 | 1.4 | 1.26–1.55 | <0.0001 | 425 (100) | 138 (100) | 0.98 | 0.85–1.13 | 0.80 | 425 (100) | 118 (100) | 0.98 | 0.84–1.14 | 0.78 | |||||||||||||
| Age at BM Diagnosis | 425 (100) | 10 (100) | 0.98 | 0.94–1.02 | 0.26 | 425 (100) | 137 (100) | 0.99 | 0.98–1.00 | 0.24 | 425 (100) | 138 (100) | 1.00 | 0.99–1.01 | 0.99 | 425 (100) | 110 (98) | 1.00 | 0.99–1.01 | 0.97 | |||||||||||||||||||
| Year of BM Diagnosis | 425 (100) | 10 (100) | 1.19 | 0.89–1.60 | 0.25 | 425 (100) | 137 (100) | 1.00 | 0.92–1.07 | 0.88 | 425 (100) | 138 (100) | 1.05 | 0.97–1.13 | 0.25 | 425 (100) | 110 (92) | 0.80 | 0.74–0.87 | <0.0001 | 0.79 | 0.73–0.86 | <0.0001 | ||||||||||||||||
| Gender: | |||||||||||||||||||||||||||||||||||||||
| Female | 121 (28) | 1 (10) | ref | 121 (28) | 38 (28) | ref | 121 (28) | 40 (29) | ref | 121 (28) | 39 (33) | ref | |||||||||||||||||||||||||||
| Male | 304 (72) | 9 (90) | 3.42 | 0.43–27.04 | 0.24 | 304 (72) | 99 (72) | 0.97 | 0.67–1.42 | 0.89 | 304 (72) | 98 (71) | 0.90 | 0.62–1.30 | 0.58 | 304 (72) | 79 (67) | 0.76 | 0.52–1.11 | 0.16 | |||||||||||||||||||
| Hemorrhage at BM Diagnosis: | |||||||||||||||||||||||||||||||||||||||
| No | 177 (42) | 4 (40) | ref | 177 (42) | 35 (26) | ref | ref | 177 (42) | 75 (54) | ref | 177 (42) | 45 (38) | ref | ref | |||||||||||||||||||||||||
| Yes | 248 (58) | 6 (60) | 1.36 | 0.38–4.87 | 0.63 | 248 (58) | 102 (74) | 2.68 | 1.82–3.94 | <0.0001 | 1.68 | 1.09–2.58 | 0.02 | 248 (58) | 63 (46) | 0.85 | 0.61–1.19 | 0.33 | 248 (58) | 73 (62) | 1.56 | 1.08–2.27 | 0.02 | 1.25 | 0.83–1.88 | 0.29 | |||||||||||||
| BRAF: | |||||||||||||||||||||||||||||||||||||||
| WT | 184 (43) | 2 (20) | ref | 184 (43) | 56 (41) | ref | 184 (43) | 72 (52) | ref | ref | 184 (43) | 43 (36) | ref | ||||||||||||||||||||||||||
| Mutated | 206 (48) | 8 (80) | 3.41 | 0.72–16.09 | 0.30 | 206 (48) | 69 (50) | 1.08 | 0.76–1.53 | 0.68 | 206 (48) | 61 (44) | 0.70 | 0.50–0.98 | 0.04 | 0.81 | 0.57–1.16 | 0.25 | 206 (48) | 63 (53) | 1.24 | 0.84–1.82 | 0.28 | ||||||||||||||||
| Pre-BM Immunotherapy: | |||||||||||||||||||||||||||||||||||||||
| No | 226 (53) | 6 (60) | ref | 226 (53) | 87 (64) | ref | ref | 226 (53) | 54 (39) | ref | ref | 226 (53) | 56 (47) | ref | |||||||||||||||||||||||||
| Yes | 199 (47) | 4 (40) | 0.77 | 0.22–2.74 | 0.69 | 199 (47) | 50 (37) | 0.67 | 0.47–0.95 | 0.02 | 0.93 | 0.65–1.35 | 0.71 | 199 (47) | 84 (61) | 1.89 | 1.34–2.66 | 0.0003 | 1.74 | 1.22–2.46 | 0.002 | 199 (47) | 62 (53) | 1.31 | 0.91–1.88 | 0.15 | |||||||||||||
| Systemic Burden at BM Diagnosis: | |||||||||||||||||||||||||||||||||||||||
| No | 42 (10) | 0 | ref | 42 (10) | 29 (22) | ref | ref | 42 (10) | 10 (7) | ref | 42 (10) | 4 (3) | ref | ||||||||||||||||||||||||||
| Yes | 372 (88) | 10 (100) | no est | no est | no est | 372 (88) | 103 (78) | 0.29 | 0.19–0.44 | <0.0001 | 0.43 | 0.28–0.68 | 0.001 | 372 (88) | 125 (93) | 0.85 | 0.45–1.63 | 0.63 | 372 (88) | 111 (97) | 2.08 | 0.77–5.65 | 0.15 | ||||||||||||||||
| Presenting Symptom: | |||||||||||||||||||||||||||||||||||||||
| Asymptomatic | 166 (39) | 2 (20) | ref | ref | 166 (39) | 19 (14) | ref | ref | 166 (39) | 78 (57) | ref | 166 (39) | 48 (41) | ref | ref | ||||||||||||||||||||||||
| Headache | 72 (17) | 4 (40) | 8.25 | 1.47–46.32 | 0.02 | 3.76 | 0.60–23.78 | 0.16 | 72 (17) | 41 (30) | 8.06 | 4.66–13.93 | <0.0001 | 3.69 | 2.05–6.64 | <0.0001 | 72 (17) | 16 (12) | 0.97 | 0.57–1.67 | 0.92 | 72 (17) | 13 (11) | 1.12 | 0.60–2.07 | 0.73 | 1.17 | 0.63–2.18 | 0.61 | ||||||||||
| Motor/sensory | 83 (20) | 2 (20) | 2.67 | 0.37–19.07 | 0.33 | 0.94 | 0.09–9.47 | 0.96 | 83 (20) | 32 (23) | 4.29 | 2.43–7.58 | <0.0001 | 1.93 | 1.03–3.60 | 0.04 | 83 (20) | 20 (14) | 0.74 | 0.45–1.21 | 0.23 | 83 (20) | 29 (25) | 1.60 | 1.01–2.54 | 0.046 | 1.13 | 0.70–1.84 | 0.62 | ||||||||||
| Seizure | 34 (8) | 0 (0) | no est | no est | no est | no est | no est | no est | 34 (8) | 13 (9) | 5.74 | 2.82–11.67 | <0.0001 | 3.23 | 1.52–6.83 | 0.002 | 34 (8) | 8 (6) | 1.17 | 0.56–2.43 | 0.67 | 34 (8) | 11 (9) | 2.17 | 1.12–4.20 | 0.02 | 1.27 | 0.64–2.53 | 0.49 | ||||||||||
| Mental status change | 56 (13) | 2 (20) | 5.17 | 0.71–37.76 | 0.11 | 2.95 | 0.37–23.43 | 0.31 | 56 (13) | 27 (20) | 6.47 | 3.59–11.68 | <0.0001 | 3.65 | 1.94–6.85 | <0.0001 | 56 (13) | 11 (8) | 0.74 | 0.39–1.40 | 0.36 | 56 (13) | 14 (12) | 1.41 | 0.78–2.57 | 0.26 | 1.22 | 0.65–2.28 | 0.54 | ||||||||||
| Other | 14 (3) | 0 (0) | no est | no est | no est | no est | no est | no est | 14 (3) | 5 (4) | 3.56 | 1.33–9.54 | 0.01 | 2.02 | 0.74–5.56 | 0.17 | 14 (3) | 5 (4) | 0.89 | 0.36–2.20 | 0.80 | 14 (3) | 3 (3) | 0.84 | 0.26–2.70 | 0.77 | 1.22 | 0.38–3.95 | 0.74 | ||||||||||
*
Variables significant in the unadjusted models were brought forward.