Table 4.
Association of local/CNS treatment modalities with overall survival.
| Unadjusted | Adjusted | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Treatment* | Level | N | % | HR | 95% CI | p-value | HR | 95% CI | p-value |
| Shunt | No | 409 | 96 | ref | ref | ||||
| Yes (time-dependent variable) | 16 | 4 | 4.14 | 2.45–6.99 | <0.0001 | 4.24 | 2.48–7.24 | <0.0001 | |
| Craniotomy | No | 269 | 63 | ref | ref | ||||
| Yes (time-dependent variable) | 156 | 37 | 0.68 | 0.53–0.86 | 0.001 | 0.72 | 0.56–0.93 | 0.0099 | |
| SRS | No | 195 | 46 | ref | ref | ||||
| Yes (time-dependent variable) | 230 | 54 | 0.59 | 0.47–0.74 | <0.0001 | 0.87 | 0.68–1.13 | 0.3 | |
| WBRT | No | 274 | 64 | ref | ref | ||||
| Yes (time-dependent variable) | 151 | 36 | 2.96 | 2.37–3.69 | <0.0001 | 2.65 | 2.08–3.38 | <0.0001 | |
*
Treatments were analyzed as time-dependent variables, performed at any time during the course of disease.