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. 2022 May 12;13(5):11923–11932. doi: 10.1080/21655979.2022.2065952

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — KIAA1429 strengthened the stability of HK2 mRNA via m⁶A-dependent manner. (a) Quantitative analysis of m⁶A in CRC cells was calculated to reveal the m⁶A quantitation of KIAA1429 overexpression (SW480) and KIAA1429 silencing (HT29). (b) RIP assay was performed in SW480 and HT29 cells to confirm the interaction between HK2 and KIAA1429. (c) MeRIP-qPCR assay followed by qRT-PCR revealed the HK2 mRNA m⁶A modification. (d) The levels of HK2 mRNA expression in KIAA1429-overexpression, KIAA1429 knockdown and their corresponding controls treated with actinomycin D (2 µg/mL). The HK2 mRNA level was detected by qRT-PCR at indicated time points. *p < 0.05; **p < 0.01.