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. 2022 Jun 5;13(5):13571–13586. doi: 10.1080/21655979.2022.2080385

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Effect of PCK1 on the chemoresistance in melanoma cells.

A. Western blot: the melanoma cell lines with low expression and overexpression of PCK1 were constructed successfully. B. IC50 figure: Knockdown of PCK1 shows low cell viability under vemurafenib, and overexpression shows high (* p < 0.05). C. Cell viability curve: the blue refers to the control, and the red refers to the knockdown (siPCK1). D. Cell viability curve: the blue represents the empty virus (EV), and the red represents the overexpression (PCK1).