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. 2022 Jun 15;13(5):13815–13828. doi: 10.1080/21655979.2022.2084460

Figure 3.

Figure 3.

miR-1225-3p is sponged by hsa_circ_0057452. (a) Schematic diagram of hsa_circ_0057452 and miR-1225-3p. (b) The relative luciferase activities were evaluated in HKFs after co-transfection with hsa_circ_0057452-WT or c hsa_circ_0057452-MUT and miR-1225-3p mimic or miR-NC, respectively. **P < 0.001 vs. miR-NC. (c) RIP assay was performed to examine the enrichment of hsa_circ_0057452 in keloid fibroblasts treated with RIP-AGO2 or RIP-IgG. **P < 0.001 vs. Anti-IgG. (d) The relative levels of miR-1225-3p were evaluated by qRT-PCR between keloid tissues (k) and normal skin (NS). **P < 0.001. (e) The relative levels of miR-1225-3p were evaluated by qRT-PCR between KFs and NFs. **P < 0.001 vs. NFs.