Table 2.

ADME(Absorption, Distribution, Metabolism, and Excretion) properties of compounds

Number	Compounds	Solubility Level	BBB Level	CYP2D6	Hepatotoxicity	Absorption Level	PPB Level
1	ZINC000014951634	3	4	0	0	3	0
2	ZINC000014951658	3	4	0	0	3	0
3	ZINC000028968101	1	4	1	1	3	1
4	ZINC000049872065	3	4	0	0	2	0
5	ZINC000002509755	2	2	1	1	0	1
6	ZINC000015122022	2	4	1	0	2	1
7	ZINC000002528486	2	2	1	1	0	1
8	ZINC000001531664	2	4	0	1	3	0
9	ZINC000013328774	3	4	0	1	3	0
10	ZINC000021992902	3	4	0	0	1	0
11	ZINC000030725991	0	4	0	1	2	0
12	ZINC000002526388	2	4	1	1	0	1
13	ZINC000008844372	3	4	0	1	1	0
14	ZINC000013378636	2	4	1	0	2	1
15	ZINC000073280937	2	4	0	1	2	1
16	ZINC000030730842	4	4	0	1	3	0
17	ZINC000006528354	3	2	0	1	0	1
18	ZINC000044281738	0	4	0	1	3	1
19	ZINC000028882432	3	4	0	0	3	0
20	ZINC000008214697	2	4	0	0	3	1
21	Ipatasertib	2	2	0	0	0	0

BBB, blood-brain barrier; CYP2D6, cytochrome P-450 2D6; PPB, plasma protein binding.

Solubility level: 0, extremely low; 1, very low, but possible; 2, low; 3, good.

BBB level: 0, very high penetrant; 1, high; 2, medium; 3, low; 4, undefined.

CYP2D6 level: 0, noninhibitor; 1, inhibitor.

Hepatotoxicity: 0, nontoxic; 1, toxic.

Human-intestinal absorption level: 0, good; 1, moderate; 2, poor; 3, very poor.

PPB: 0, absorbent weak; 1, absorbent strong.