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. 2022 May 20;13(5):12309–12325. doi: 10.1080/21655979.2022.2072619

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — miR-744-5p is downregulated in osteosarcoma cell lines and clinical tissues. (a) Volcano plot demonstrated the expressive diversity of miRNAs between OS and normal tissues from GSE65071. (b) The cluster heat map showed the upregulated and downregulated miRNAs in GSE65071. (c) The top 10 downregulated miRNAs are listed. (d) The relative expression of miR-744-5p was remarkably suppressed in OS cell lines. (e) Expression of miR-744-5p was significantly downregulated in OS clinical tissues than in para-carcinoma tissues. * p < 0.05, ** p < 0.01, *** p < 0.001.